Palm or skin can be hard due to a variety of reasons. One reason is occupational, frictional dermatosis. People who work in very rough occupations where the palm or skin can be hard or thickened and can feel bit uncomfortable for the person. Other skin condition’s like palmar psoriasis can cause thickening of the skin on the palms. Certain diseases like palmar plantar keratoderma, which are inherited skin disease, can also cause thickening of the palms and the soles. These skin thickenings can be treated by using topical formulations or in certain cases strong medications containing Vitamin A . Synthetic Vitamin A derivatives can be used.
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