As the focus moves on from the face to the hands we have consideration that the skin on the hands and especially the knuckles can get especially dark. This can happen as a result of Vitamin deficiency especially vitamin B12 deficiency, which could be having a megaloblastic anaemia component, so if you are feeling that the knuckles have become dark, make sure that you speak to your dermatologist, they can do very simple blood tests and you may be able to treat the dark circles very well. If you don’t have the pigmentary deficiency, the you have to think about other conditions lie what kind of contact things that you are coming to. It can be simple chemicals like detergents or something which you are pointing with that can develop the skin to be allergic and secondly it can be hyperpigmented, so when you talk about dark knuckles, it is best to take a specialist opinion so that they can have an examination, then decide whether it is a vitamin deficiency or it is a skin problem that it needs special attention.
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